Characteristics	Details
Chemical Name	Sitagliptin
Dosage Form	Tablets
Strengths Available	25 mg, 50 mg, 100 mg
Usage	Type 2 Diabetes Mellitus
Learn More About Januvia

Chemical Structure and Properties

The active compound in Januvia, sitagliptin, belongs to the class of medications known as dipeptidyl peptidase-4 (DPP-4) inhibitors. Its molecular formula is C16H15F6N5O. Sitagliptin’s crystalline form allows for consistent stability and efficacy. The chemical structure facilitates its role in enhancing glycemic control by prolonging the activity of incretin hormones, which are pivotal in managing blood glucose levels. These hormones increase insulin release and decrease glucagon levels in the circulation in a glucose-dependent manner.

Dosage Information and Administration

Januvia 100 mg tablets represent the typical prescribed dose for the majority of patients with type 2 diabetes. However, adjustments are necessary for individuals with renal impairment. Healthcare providers often recommend lower doses, such as 50 mg or 25 mg, depending on the severity of kidney dysfunction. Patients should ingest the tablet orally, with or without food. Consistency in daily intake timing enhances therapeutic outcomes. Physicians advise adherence to prescribed regimens to avoid suboptimal glycemic control.

Contraindications for Januvia Usage

Januvia is not suitable for individuals with type 1 diabetes or diabetic ketoacidosis. The medication is contraindicated in patients with a history of serious hypersensitivity reactions to sitagliptin, such as anaphylaxis or angioedema. Careful consideration is necessary for patients with pancreatitis history, as there have been reports of acute pancreatitis in some users. Studies suggest monitoring for any signs of pancreatitis while on Januvia therapy.

Proper Storage Conditions for Januvia

Store Januvia tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). Keep the medication in its original packaging to protect from moisture and light. Do not store in bathroom cabinets where humidity levels are higher. Ensure that the storage area is out of reach of children to prevent accidental ingestion. Proper storage ensures the medication’s effectiveness and stability.

Recognizing Signs and Symptoms of Overdose

Overdose of Januvia 50 mg can manifest through several symptoms. Common indications include dizziness, rapid heartbeat, and extreme fatigue. More severe symptoms may involve severe hypoglycemia, which requires prompt medical attention. If an overdose is suspected, immediate consultation with healthcare professionals is imperative. They might initiate supportive measures and glucose monitoring to address potential complications.

Availability of Non-Prescription Januvia

Januvia is a prescription medication and is not available for purchase over-the-counter. Its dispensation requires a healthcare provider’s prescription to ensure that it is used safely and appropriately. Regular consultation with healthcare professionals ensures the monitoring of the patient’s response to therapy and any necessary adjustments. It is crucial for patients to discuss their full medical history and current medications with their healthcare provider to prevent adverse interactions.

Aspect	Details
Mechanism of Action	DPP-4 Inhibition
Main Component	Sitagliptin
Administration	Oral

Consult healthcare providers for personalized advice.
Monitor blood sugar levels regularly.
Adhere to prescribed dosage and schedule.

Source:

Januvia: Comprehensive Medication Overview